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Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation

Casitas B-lineage lymphoma-b (Cbl-b) is an E3 ubiquitin ligase that negatively regulates T cell activation. Cbl-b(−/−) T cells are hyper-reactive and co-stimulation independent, and Cbl-b(−/−) mice demonstrate robust T cell and NK cell-mediated antitumor immunity. As a result of these murine studies...

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Detalles Bibliográficos
Autores principales:	Fujiwara, Mai, Anstadt, Emily J., Clark, Robert B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266705/ https://www.ncbi.nlm.nih.gov/pubmed/28184224 http://dx.doi.org/10.3389/fimmu.2017.00042

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