MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit

BACKGROUND: Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and causative for multiple endocrine neoplasia (MEN) type 2A and 2B. These tumors are highly aggressive with a high propensity for...

Descripción completa

Detalles Bibliográficos
Autores principales: Spitschak, Alf, Meier, Claudia, Kowtharapu, Bhavani, Engelmann, David, Pützer, Brigitte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267421/
https://www.ncbi.nlm.nih.gov/pubmed/28122586
http://dx.doi.org/10.1186/s12943-016-0563-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267421/
https://www.ncbi.nlm.nih.gov/pubmed/28122586
http://dx.doi.org/10.1186/s12943-016-0563-x

Ejemplares similares