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MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit

BACKGROUND: Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and causative for multiple endocrine neoplasia (MEN) type 2A and 2B. These tumors are highly aggressive with a high propensity for...

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Detalles Bibliográficos
Autores principales:	Spitschak, Alf, Meier, Claudia, Kowtharapu, Bhavani, Engelmann, David, Pützer, Brigitte M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267421/ https://www.ncbi.nlm.nih.gov/pubmed/28122586 http://dx.doi.org/10.1186/s12943-016-0563-x

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