Of yeast, mice and men: MAMs come in two flavors

The past decade has seen dramatic progress in our understanding of membrane contact sites (MCS). Important examples of these are endoplasmic reticulum (ER)-mitochondria contact sites. ER-mitochondria contacts have originally been discovered in mammalian tissue, where they have been designated as mit...

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Autores principales: Herrera-Cruz, Maria Sol, Simmen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267431/
https://www.ncbi.nlm.nih.gov/pubmed/28122638
http://dx.doi.org/10.1186/s13062-017-0174-5
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author Herrera-Cruz, Maria Sol
Simmen, Thomas
author_facet Herrera-Cruz, Maria Sol
Simmen, Thomas
author_sort Herrera-Cruz, Maria Sol
collection PubMed
description The past decade has seen dramatic progress in our understanding of membrane contact sites (MCS). Important examples of these are endoplasmic reticulum (ER)-mitochondria contact sites. ER-mitochondria contacts have originally been discovered in mammalian tissue, where they have been designated as mitochondria-associated membranes (MAMs). It is also in this model system, where the first critical MAM proteins have been identified, including MAM tethering regulators such as phospho-furin acidic cluster sorting protein 2 (PACS-2) and mitofusin-2. However, the past decade has seen the discovery of the MAM also in the powerful yeast model system Saccharomyces cerevisiae. This has led to the discovery of novel MAM tethers such as the yeast ER-mitochondria encounter structure (ERMES), absent in the mammalian system, but whose regulators Gem1 and Lam6 are conserved. While MAMs, sometimes referred to as mitochondria-ER contacts (MERCs), regulate lipid metabolism, Ca(2+) signaling, bioenergetics, inflammation, autophagy and apoptosis, not all of these functions exist in both systems or operate differently. This biological difference has led to puzzling discrepancies on findings obtained in yeast or mammalian cells at the moment. Our review aims to shed some light onto mechanistic differences between yeast and mammalian MAM and their underlying causes. Reviewers: This article was reviewed by Paola Pizzo (nominated by Luca Pellegrini), Maya Schuldiner and György Szabadkai (nominated by Luca Pellegrini).
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spelling pubmed-52674312017-02-01 Of yeast, mice and men: MAMs come in two flavors Herrera-Cruz, Maria Sol Simmen, Thomas Biol Direct Review The past decade has seen dramatic progress in our understanding of membrane contact sites (MCS). Important examples of these are endoplasmic reticulum (ER)-mitochondria contact sites. ER-mitochondria contacts have originally been discovered in mammalian tissue, where they have been designated as mitochondria-associated membranes (MAMs). It is also in this model system, where the first critical MAM proteins have been identified, including MAM tethering regulators such as phospho-furin acidic cluster sorting protein 2 (PACS-2) and mitofusin-2. However, the past decade has seen the discovery of the MAM also in the powerful yeast model system Saccharomyces cerevisiae. This has led to the discovery of novel MAM tethers such as the yeast ER-mitochondria encounter structure (ERMES), absent in the mammalian system, but whose regulators Gem1 and Lam6 are conserved. While MAMs, sometimes referred to as mitochondria-ER contacts (MERCs), regulate lipid metabolism, Ca(2+) signaling, bioenergetics, inflammation, autophagy and apoptosis, not all of these functions exist in both systems or operate differently. This biological difference has led to puzzling discrepancies on findings obtained in yeast or mammalian cells at the moment. Our review aims to shed some light onto mechanistic differences between yeast and mammalian MAM and their underlying causes. Reviewers: This article was reviewed by Paola Pizzo (nominated by Luca Pellegrini), Maya Schuldiner and György Szabadkai (nominated by Luca Pellegrini). BioMed Central 2017-01-25 /pmc/articles/PMC5267431/ /pubmed/28122638 http://dx.doi.org/10.1186/s13062-017-0174-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Herrera-Cruz, Maria Sol
Simmen, Thomas
Of yeast, mice and men: MAMs come in two flavors
title Of yeast, mice and men: MAMs come in two flavors
title_full Of yeast, mice and men: MAMs come in two flavors
title_fullStr Of yeast, mice and men: MAMs come in two flavors
title_full_unstemmed Of yeast, mice and men: MAMs come in two flavors
title_short Of yeast, mice and men: MAMs come in two flavors
title_sort of yeast, mice and men: mams come in two flavors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267431/
https://www.ncbi.nlm.nih.gov/pubmed/28122638
http://dx.doi.org/10.1186/s13062-017-0174-5
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