Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines

BACKGROUND: Positive and negative feedback loops are ubiquitous motifs in biochemical signaling pathways. The mitogen-activated protein kinase (MAPK) pathway module is part of many distinct signaling networks and comprises several of these motifs, whose functioning depends on the cell line at hand a...

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Detalles Bibliográficos
Autores principales: Jensch, Antje, Thomaseth, Caterina, Radde, Nicole E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267478/
https://www.ncbi.nlm.nih.gov/pubmed/28122551
http://dx.doi.org/10.1186/s12918-017-0392-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267478/
https://www.ncbi.nlm.nih.gov/pubmed/28122551
http://dx.doi.org/10.1186/s12918-017-0392-6

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