A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

The master spindle checkpoint kinase Mps1 senses kinetochore-microtubule attachment and promotes checkpoint signaling to ensure accurate chromosome segregation. The kinetochore scaffold Knl1, when phosphorylated by Mps1, recruits checkpoint complexes Bub1–Bub3 and BubR1–Bub3 to unattached kinetochor...

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Detalles Bibliográficos
Autores principales: Ji, Zhejian, Gao, Haishan, Jia, Luying, Li, Bing, Yu, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268738/
https://www.ncbi.nlm.nih.gov/pubmed/28072388
http://dx.doi.org/10.7554/eLife.22513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268738/
https://www.ncbi.nlm.nih.gov/pubmed/28072388
http://dx.doi.org/10.7554/eLife.22513

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