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Differential Feedback Regulation of Δ(4)-3-Oxosteroid 5β-Reductase Expression by Bile Acids
Δ(4)-3-oxosteroid 5β-reductase is member D1 of the aldo-keto reductase family 1 (AKR1D1), which catalyzes 5β-reduction of molecules with a 3-oxo-4-ene structure. Bile acid intermediates and most of the steroid hormones carry the 3-oxo-4-ene structure. Therefore, AKR1D1 plays critical roles in both b...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268776/ https://www.ncbi.nlm.nih.gov/pubmed/28125709 http://dx.doi.org/10.1371/journal.pone.0170960 |