Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1

[Image: see text] Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, esters, and carbonates. Structurally, PON1 is a six-bladed β-propeller with a flexible loop (residues 70–81) covering the active site. This...

Descripción completa

Detalles Bibliográficos
Autores principales: Blaha-Nelson, David, Krüger, Dennis M., Szeler, Klaudia, Ben-David, Moshe, Kamerlin, Shina Caroline Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269640/
https://www.ncbi.nlm.nih.gov/pubmed/28026940
http://dx.doi.org/10.1021/jacs.6b10801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269640/
https://www.ncbi.nlm.nih.gov/pubmed/28026940
http://dx.doi.org/10.1021/jacs.6b10801

Ejemplares similares