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Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase
[Image: see text] Inhibitor design incorporating features of the reaction coordinate and transition-state structure has emerged as a powerful approach for the development of enzyme inhibitors. Such inhibitors find use as mechanistic probes, chemical biology tools, and therapeutics. Endo-α-1,2-mannos...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269645/ https://www.ncbi.nlm.nih.gov/pubmed/27992199 http://dx.doi.org/10.1021/jacs.6b10075 |