Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase

[Image: see text] Inhibitor design incorporating features of the reaction coordinate and transition-state structure has emerged as a powerful approach for the development of enzyme inhibitors. Such inhibitors find use as mechanistic probes, chemical biology tools, and therapeutics. Endo-α-1,2-mannos...

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Detalles Bibliográficos
Autores principales: Petricevic, Marija, Sobala, Lukasz F., Fernandes, Pearl Z., Raich, Lluís, Thompson, Andrew J., Bernardo-Seisdedos, Ganeko, Millet, Oscar, Zhu, Sha, Sollogoub, Matthieu, Jiménez-Barbero, Jesús, Rovira, Carme, Davies, Gideon J., Williams, Spencer J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269645/
https://www.ncbi.nlm.nih.gov/pubmed/27992199
http://dx.doi.org/10.1021/jacs.6b10075

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