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Scalable Synthesis of (−)-Thapsigargin

[Image: see text] Total syntheses of the complex, highly oxygenated sesquiterpenes thapsigargin (1) and nortrilobolide (2) are presented. Access to analogues of these promising bioactive natural products has been limited to tedious isolation and semisynthetic efforts. Elegant prior total syntheses d...

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Detalles Bibliográficos
Autores principales:	Chu, Hang, Smith, Joel M., Felding, Jakob, Baran, Phil S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269647/ https://www.ncbi.nlm.nih.gov/pubmed/28149952 http://dx.doi.org/10.1021/acscentsci.6b00313

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