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Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping
Therapeutic and diagnostic applications of monoclonal antibodies often require careful selection of binders that recognize specific epitopes on the target molecule to exert a desired modulation of biological function. Here we present a proof-of-concept application for the rational design of an epito...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269676/ https://www.ncbi.nlm.nih.gov/pubmed/28128368 http://dx.doi.org/10.1038/srep41306 |