Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping

Therapeutic and diagnostic applications of monoclonal antibodies often require careful selection of binders that recognize specific epitopes on the target molecule to exert a desired modulation of biological function. Here we present a proof-of-concept application for the rational design of an epito...

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Detalles Bibliográficos
Autores principales: Liu, Xiaofeng, Taylor, Richard D., Griffin, Laura, Coker, Shu-Fen, Adams, Ralph, Ceska, Tom, Shi, Jiye, Lawson, Alastair D. G., Baker, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269676/
https://www.ncbi.nlm.nih.gov/pubmed/28128368
http://dx.doi.org/10.1038/srep41306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269676/
https://www.ncbi.nlm.nih.gov/pubmed/28128368
http://dx.doi.org/10.1038/srep41306

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