The spleen microenvironment influences disease transformation in a mouse model of KIT(D816V)-dependent myeloproliferative neoplasm

Activating mutations leading to ligand-independent signaling of the stem cell factor receptor KIT are associated with several hematopoietic malignancies. One of the most common alterations is the D816V mutation. In this study, we characterized mice, which conditionally express the humanized KIT(D816...

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Detalles Bibliográficos
Autores principales: Pelusi, Natalie, Kosanke, Maike, Riedt, Tamara, Rösseler, Corinna, Seré, Kristin, Li, Jin, Gütgemann, Ines, Zenke, Martin, Janzen, Viktor, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269732/
https://www.ncbi.nlm.nih.gov/pubmed/28128288
http://dx.doi.org/10.1038/srep41427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269732/
https://www.ncbi.nlm.nih.gov/pubmed/28128288
http://dx.doi.org/10.1038/srep41427

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