RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP

Multifunctional RNA helicase DDX3 participates in HCV infection, one of the major causes of hepatic steatosis. Here, we investigated the role of DDX3 in hepatic lipid metabolism. We found that HCV infection severely reduced DDX3 expression. Analysis of intracellular triglyceride and secreted ApoB in...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsai, Tsung-Yuan, Wang, Wei-Ting, Li, Hao-Kang, Chen, Wei-Ju, Tsai, Yu-Hong, Chao, Chi-Hong, Wu Lee, Yan-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269733/
https://www.ncbi.nlm.nih.gov/pubmed/28128295
http://dx.doi.org/10.1038/srep41452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269733/
https://www.ncbi.nlm.nih.gov/pubmed/28128295
http://dx.doi.org/10.1038/srep41452

Ejemplares similares