Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains

Antibody light chain amyloidosis is a rare disease caused by fibril formation of secreted immunoglobulin light chains (LCs). The huge variety of antibody sequences puts a serious challenge to drug discovery. The green tea polyphenol epigallocatechin-3-gallate (EGCG) is known to interfere with fibril...

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Detalles Bibliográficos
Autores principales: Hora, Manuel, Carballo-Pacheco, Martin, Weber, Benedikt, Morris, Vanessa K., Wittkopf, Antje, Buchner, Johannes, Strodel, Birgit, Reif, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269747/
https://www.ncbi.nlm.nih.gov/pubmed/28128355
http://dx.doi.org/10.1038/srep41515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269747/
https://www.ncbi.nlm.nih.gov/pubmed/28128355
http://dx.doi.org/10.1038/srep41515

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