Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro

Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but their therapeutic benefits are compromised by severe side effects. To address this concern, here we developed a potent “hit” c...

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Detalles Bibliográficos
Autores principales: Yi, Wei, Shi, Jingjing, Zhao, Guanguan, Zhou, X. Edward, Suino-Powell, Kelly, Melcher, Karsten, Xu, H. Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270246/
https://www.ncbi.nlm.nih.gov/pubmed/28128331
http://dx.doi.org/10.1038/srep41487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270246/
https://www.ncbi.nlm.nih.gov/pubmed/28128331
http://dx.doi.org/10.1038/srep41487

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