Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia

Inducing degradation of oncoproteins by small molecule compounds has the potential to avoid drug resistance and therefore deserves to be exploited for new therapies. Oridonin is a natural compound with promising antitumor efficacy that can trigger the degradation of oncoproteins; however, the direct...

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Detalles Bibliográficos
Autores principales: Huang, Huilin, Weng, Hengyou, Dong, Bowen, Zhao, Panpan, Zhou, Hui, Qu, Lianghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270248/
https://www.ncbi.nlm.nih.gov/pubmed/28128329
http://dx.doi.org/10.1038/srep41525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270248/
https://www.ncbi.nlm.nih.gov/pubmed/28128329
http://dx.doi.org/10.1038/srep41525

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