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Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia
Inducing degradation of oncoproteins by small molecule compounds has the potential to avoid drug resistance and therefore deserves to be exploited for new therapies. Oridonin is a natural compound with promising antitumor efficacy that can trigger the degradation of oncoproteins; however, the direct...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270248/ https://www.ncbi.nlm.nih.gov/pubmed/28128329 http://dx.doi.org/10.1038/srep41525 |