The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca(2+) Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

A number of point mutations in the intracellular Ca(2+)-sensing protein calmodulin (CaM) are arrhythmogenic, yet their underlying mechanisms are not clear. These mutations generally decrease Ca(2+) binding to CaM and impair inhibition of CaM-regulated Ca(2+) channels like the cardiac Ca(2+) release...

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Detalles Bibliográficos
Autores principales: Søndergaard, Mads Toft, Liu, Yingjie, Larsen, Kamilla Taunsig, Nani, Alma, Tian, Xixi, Holt, Christian, Wang, Ruiwu, Wimmer, Reinhard, Van Petegem, Filip, Fill, Michael, Chen, S. R. Wayne, Overgaard, Michael Toft
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270481/
https://www.ncbi.nlm.nih.gov/pubmed/27927985
http://dx.doi.org/10.1074/jbc.M116.766253

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