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The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca(2+) Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor
A number of point mutations in the intracellular Ca(2+)-sensing protein calmodulin (CaM) are arrhythmogenic, yet their underlying mechanisms are not clear. These mutations generally decrease Ca(2+) binding to CaM and impair inhibition of CaM-regulated Ca(2+) channels like the cardiac Ca(2+) release...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270481/ https://www.ncbi.nlm.nih.gov/pubmed/27927985 http://dx.doi.org/10.1074/jbc.M116.766253 |