Ca(2+)-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

The Ca(2+) sensor calmodulin (CaM) regulates cardiac ryanodine receptor (RyR2)-mediated Ca(2+) release from the sarcoplasmic reticulum. CaM inhibits RyR2 in a Ca(2+)-dependent manner and aberrant CaM-dependent inhibition results in life-threatening cardiac arrhythmias. However, the molecular details...

Descripción completa

Detalles Bibliográficos
Autores principales: Brohus, Malene, Søndergaard, Mads T., Wayne Chen, Sui Rong, vanPetegem, Filip, Overgaard, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340113/
https://www.ncbi.nlm.nih.gov/pubmed/30530841
http://dx.doi.org/10.1042/BCJ20180545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340113/
https://www.ncbi.nlm.nih.gov/pubmed/30530841
http://dx.doi.org/10.1042/BCJ20180545

Ejemplares similares