Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome

PURPOSE: To evaluate the efficacy of topical rapamycin in treating autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. METHODS: We developed rapamycin in a poly(ethylene glycol)-distearoyl phosphatidylethanolamine (PEG-DSPE) micelle formulation to maintain solubility. Rapamycin or...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Mihir, Edman, Maria C., Reddy Janga, Srikanth, Yarber, Frances, Meng, Zhen, Klinngam, Wannita, Bushman, Jonathan, Ma, Tao, Liu, Siyu, Louie, Stan, Mehta, Arjun, Ding, Chuanqing, MacKay, J. Andrew, Hamm-Alvarez, Sarah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270623/
https://www.ncbi.nlm.nih.gov/pubmed/28122086
http://dx.doi.org/10.1167/iovs.16-19159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270623/
https://www.ncbi.nlm.nih.gov/pubmed/28122086
http://dx.doi.org/10.1167/iovs.16-19159

Ejemplares similares