Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging

Centenarians not only enjoy an extraordinary aging, but also show a compression of morbidity. Using functional transcriptomic analysis of peripheral blood mononuclear cells (PMBC) we identified 1721 mRNAs differentially expressed by centenarians when compared with septuagenarians and young people. S...

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Detalles Bibliográficos
Autores principales: Borras, Consuelo, M. Abdelaziz, Kheira, Gambini, Juan, Serna, Eva, Inglés, Marta, de la Fuente, Monica, Garcia, Idoia, Matheu, Ander, Sanchís, Paula, Belenguer, Angel, Errigo, Alessandra, Avellana, Juan- Antonio, Barettino, Ana, Lloret-Fernández, Carla, Flames, Nuria, Pes, Gianni, Rodriguez-Mañas, Leocadio, Viña, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270663/
https://www.ncbi.nlm.nih.gov/pubmed/27794564
http://dx.doi.org/10.18632/aging.101078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270663/
https://www.ncbi.nlm.nih.gov/pubmed/27794564
http://dx.doi.org/10.18632/aging.101078

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