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Modulation of Human Cardiac TRPM7 Current by Extracellular Acidic pH Depends upon Extracellular Concentrations of Divalent Cations

TRPM7 channels participate in a variety of physiological/pathological processes. TRPM7 currents are modulated by protons but opposing effects of external pH (pH(o)) (potentiation vs inhibition) have been reported. TRPM7 has been less studied in human cardiomyocytes than in heart-derived non-cardiomy...

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Detalles Bibliográficos
Autores principales: Mačianskienė, Regina, Almanaitytė, Mantė, Jekabsone, Aistė, Mubagwa, Kanigula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271359/
https://www.ncbi.nlm.nih.gov/pubmed/28129376
http://dx.doi.org/10.1371/journal.pone.0170923