A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Aldehyde dehydrogenase enzymes (ALDHs) have a broad spectrum of biological activities through the oxidation of both endogenous and exogenous aldehydes. Increased expression of ALDH1A1 has been identified in a wide-range of human cancer stem cells and is associated with cancer relapse and poor progno...

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Detalles Bibliográficos
Autores principales: Yasgar, Adam, Titus, Steven A., Wang, Yuhong, Danchik, Carina, Yang, Shyh-Ming, Vasiliou, Vasilis, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Martinez, Natalia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271370/
https://www.ncbi.nlm.nih.gov/pubmed/28129349
http://dx.doi.org/10.1371/journal.pone.0170937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271370/
https://www.ncbi.nlm.nih.gov/pubmed/28129349
http://dx.doi.org/10.1371/journal.pone.0170937

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