Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

We show that epigenome- and transcriptome-wide association studies (EWAS and TWAS) are prone to significant inflation and bias of test statistics, an unrecognized phenomenon introducing spurious findings if left unaddressed. Neither GWAS-based methodology nor state-of-the-art confounder adjustment m...

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Detalles Bibliográficos
Autores principales: van Iterson, Maarten, van Zwet, Erik W., Heijmans, Bastiaan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5273857/
https://www.ncbi.nlm.nih.gov/pubmed/28129774
http://dx.doi.org/10.1186/s13059-016-1131-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5273857/
https://www.ncbi.nlm.nih.gov/pubmed/28129774
http://dx.doi.org/10.1186/s13059-016-1131-9

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