Investigation of the interactions of critical scale-up parameters (pH, pO(2) and pCO(2)) on CHO batch performance and critical quality attributes

Understanding process parameter interactions and their effects on mammalian cell cultivations is an essential requirement for robust process scale-up. Furthermore, knowledge of the relationship between the process parameters and the product critical quality attributes (CQAs) is necessary to satisfy...

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Detalles Bibliográficos
Autores principales: Brunner, Matthias, Fricke, Jens, Kroll, Paul, Herwig, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274649/
https://www.ncbi.nlm.nih.gov/pubmed/27752770
http://dx.doi.org/10.1007/s00449-016-1693-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274649/
https://www.ncbi.nlm.nih.gov/pubmed/27752770
http://dx.doi.org/10.1007/s00449-016-1693-7

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