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Investigation of the interactions of critical scale-up parameters (pH, pO(2) and pCO(2)) on CHO batch performance and critical quality attributes
Understanding process parameter interactions and their effects on mammalian cell cultivations is an essential requirement for robust process scale-up. Furthermore, knowledge of the relationship between the process parameters and the product critical quality attributes (CQAs) is necessary to satisfy...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274649/ https://www.ncbi.nlm.nih.gov/pubmed/27752770 http://dx.doi.org/10.1007/s00449-016-1693-7 |