Utilising polymorphisms to achieve allele-specific genome editing in zebrafish

The advent of genome editing has significantly altered genetic research, including research using the zebrafish model. To better understand the selectivity of the commonly used CRISPR/Cas9 system, we investigated single base pair mismatches in target sites and examined how they affect genome editing...

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Detalles Bibliográficos
Autores principales: Capon, Samuel J., Baillie, Gregory J., Bower, Neil I., da Silva, Jason A., Paterson, Scott, Hogan, Benjamin M., Simons, Cas, Smith, Kelly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Methods & Techniques
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278422/
https://www.ncbi.nlm.nih.gov/pubmed/27895053
http://dx.doi.org/10.1242/bio.020974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278422/
https://www.ncbi.nlm.nih.gov/pubmed/27895053
http://dx.doi.org/10.1242/bio.020974

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