Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis

Previously, we showed that mutations in Mycobacterium tuberculosis panD, involved in coenzyme A biosynthesis, cause resistance against pyrazinoic acid, the bioactive component of the prodrug pyrazinamide. To identify additional resistance mechanisms, we isolated mutants resistant against pyrazinoic...

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Detalles Bibliográficos
Autores principales: Yee, Michelle, Gopal, Pooja, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278685/
https://www.ncbi.nlm.nih.gov/pubmed/27872068
http://dx.doi.org/10.1128/AAC.02342-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278685/
https://www.ncbi.nlm.nih.gov/pubmed/27872068
http://dx.doi.org/10.1128/AAC.02342-16

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