Structure-Activity Relationships of a Series of Echinocandins and the Discovery of CD101, a Highly Stable and Soluble Echinocandin with Distinctive Pharmacokinetic Properties

Echinocandins are a first-line therapy for candidemia and invasive candidiasis. They are generally safe with few drug interactions, but the stability and pharmacokinetic properties of currently approved echinocandins are such that each was developed for daily intravenous infusion. We sought to disco...

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Detalles Bibliográficos
Autores principales: James, Kenneth D., Laudeman, Christopher P., Malkar, Navdeep B., Krishnan, Radha, Polowy, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278707/
https://www.ncbi.nlm.nih.gov/pubmed/27919891
http://dx.doi.org/10.1128/AAC.01541-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278707/
https://www.ncbi.nlm.nih.gov/pubmed/27919891
http://dx.doi.org/10.1128/AAC.01541-16

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