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Statistical design considerations for pilot studies transitioning therapies from the bench to the bedside
Pilot studies are often used to transition therapies developed using animal models to a clinical setting. Frequently, the focus of such trials is on estimating the safety in terms of the occurrence of certain adverse events. With relatively small sample sizes, the probability of observing even relat...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC527875/ https://www.ncbi.nlm.nih.gov/pubmed/15511289 http://dx.doi.org/10.1186/1479-5876-2-37 |