Cargando…
Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction
Affinity maturation is a Darwinian process in which B lymphocytes evolve potent antibodies to encountered antigens and generate immune memory. Highly mutable complex pathogens present an immense antigenic diversity that continues to challenge natural immunity and vaccine design. Induction of broadly...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279722/ https://www.ncbi.nlm.nih.gov/pubmed/28135270 http://dx.doi.org/10.1371/journal.pcbi.1005336 |