Cargando…

Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice

The vitamin B(12) analog hydroxy-cobalamin[c-lactam] (HCCL) impairs hepatic mitochondrial protein synthesis and function of the electron transport chain in rats. We aimed to establish an in vivo model for mitochondrial dysfunction in mice, which could be used to investigate hepatotoxicity of mitocho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haegler, Patrizia, Grünig, David, Berger, Benjamin, Terracciano, Luigi, Krähenbühl, Stephan, Bouitbir, Jamal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279765/ https://www.ncbi.nlm.nih.gov/pubmed/28135329 http://dx.doi.org/10.1371/journal.pone.0171026

Ejemplares similares

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency
por: Bouitbir, Jamal, et al.
Publicado: (2016)

Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression
por: Panajatovic, Miljenko V., et al.
Publicado: (2021)

Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression
por: Panajatovic, Miljenko Valentin, et al.
Publicado: (2020)

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis
por: Paech, Franziska, et al.
Publicado: (2017)

Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells
por: Sanvee, Gerda M., et al.
Publicado: (2019)

Mitochondrial Toxicity Associated with Imatinib and Sorafenib in Isolated Rat Heart Fibers and the Cardiomyoblast H9c2 Cell Line
por: Bouitbir, Jamal, et al.
Publicado: (2022)

Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells
por: Roos, Noëmi Johanna, et al.
Publicado: (2020)

Acute Liver Failure in a Patient Treated With Metamizole
por: Krisai, Philipp, et al.
Publicado: (2019)

Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient
por: Bühler, Tim, et al.
Publicado: (2019)

Reactive Metamizole Metabolites Enhance the Toxicity of Hemin on the ATP Pool in HL60 Cells by Inhibition of Glycolysis
por: Rudin, Deborah, et al.
Publicado: (2020)

Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells
por: Bouitbir, Jamal, et al.
Publicado: (2020)

Para-Halogenation of Amphetamine and Methcathinone Increases the Mitochondrial Toxicity in Undifferentiated and Differentiated SH-SY5Y Cells
por: Zhou, Xun, et al.
Publicado: (2020)

Hyperthermia Increases Neurotoxicity Associated with Novel Methcathinones
por: Zhou, Xun, et al.
Publicado: (2020)

Exogenous Iron Increases Fasciocidal Activity and Hepatocellular Toxicity of the Synthetic Endoperoxides OZ78 and MT04
por: Brecht, Karin, et al.
Publicado: (2019)

Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts
por: Zhou, Xun, et al.
Publicado: (2019)

Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency
por: Obeid, Rima, et al.
Publicado: (2015)

PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle
por: Novakova, Katerina, et al.
Publicado: (2022)

Review of cobalamin status and disorders of cobalamin metabolism in dogs
por: Kather, Stefanie, et al.
Publicado: (2019)

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells
por: Grünig, David, et al.
Publicado: (2018)

Mechanisms of Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in H9c2 Cells and Mice
por: Bouitbir, J, et al.
Publicado: (2020)

Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently
por: Duthaler, Urs, et al.
Publicado: (2022)

Cobalamin Deficiency in the Elderly
por: Marchi, Giacomo, et al.
Publicado: (2020)

Cobalamin deficiency in pregnancy
por: Konings, Heleen, et al.
Publicado: (2021)

Cobalamin Related Parameters and Disease Patterns in Patients with Increased Serum Cobalamin Levels
por: Arendt, Johan F. B., et al.
Publicado: (2012)

Statins and Insulin Resistance
por: Sanvee, GM, et al.
Publicado: (2020)

The Cobalamin-Binding Protein in Zebrafish Is an Intermediate between the Three Cobalamin-Binding Proteins in Human
por: Greibe, Eva, et al.
Publicado: (2012)

Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity
por: Panajatovic, M, et al.
Publicado: (2020)

Cobalamin deficiency, hyperhomocysteinemia, and dementia
por: Werder, Steven F
Publicado: (2010)

Nitrosyl- versus nitroxyl-cobalamin?
por: Polaczek, Justyna, et al.
Publicado: (2019)

Rats with Long-Term Cholestasis Have a Decreased Cytosolic but Maintained Mitochondrial Hepatic CoA Pool
por: Krähenbühl, Lukas, et al.
Publicado: (2023)

De Novo Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in Mycobacterium smegmatis
por: Kipkorir, Terry, et al.
Publicado: (2021)

Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study
por: Blaser, Lea S, et al.
Publicado: (2021)

Nickel-Catalyzed Amidoalkylation Reaction of γ-Hydroxy Lactams: An Access to 3-Substituted Isoindolinones†
por: Zhang, Shuo, et al.
Publicado: (2019)

Influence of Cobalamin on Arsenic Metabolism in Bangladesh
por: Hall, Megan N., et al.
Publicado: (2009)

The effects of Cobalamin and B-complex on hypermenorrhea
por: Yassaee, Fakhrolmolouk, et al.
Publicado: (2020)

Linagliptin treatment is associated with altered cobalamin (VitB12) homeostasis in mice and humans
por: Tammen, Harald, et al.
Publicado: (2023)

Cobalamin Deficiency: Clinical Picture and Radiological Findings
por: Briani, Chiara, et al.
Publicado: (2013)

Molecular basis of cobalamin-dependent RNA modification
por: Dowling, Daniel P., et al.
Publicado: (2016)

An In Vitro Model of Gastric Inflammation and Treatment with Cobalamin
por: Elliott, T. R., et al.
Publicado: (2017)

Assessment of cellular cobalamin metabolism in Gaucher disease
por: Basgalupp, Suelen Porto, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_avlcldd18321r83hi0m8eaj184