Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes

Autophagy dysfunction is considered as a potential toxic mechanism of nanomaterials. Silica nanoparticles (SiNPs) can induce autophagy, but the specific mechanism involved remains unclear. Therefore, the aim of this study was to confirm the effects of SiNPs on autophagy dysfunction and explore the p...

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Detalles Bibliográficos
Autores principales: Wang, Ji, Yu, Yongbo, Lu, Ke, Yang, Man, Li, Yang, Zhou, Xianqing, Sun, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279829/
https://www.ncbi.nlm.nih.gov/pubmed/28182147
http://dx.doi.org/10.2147/IJN.S123596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279829/
https://www.ncbi.nlm.nih.gov/pubmed/28182147
http://dx.doi.org/10.2147/IJN.S123596

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