The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

Fibronectin (FN), a major extracellular matrix component, enables integrin-mediated cell adhesion via binding of α5β1, αIIbβ3 and αv-class integrins to an RGD-motif. An additional linkage for α5 and αIIb is the synergy site located in close proximity to the RGD motif. We report that mice with a dysf...

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Detalles Bibliográficos
Autores principales: Benito-Jardón, Maria, Klapproth, Sarah, Gimeno-LLuch, Irene, Petzold, Tobias, Bharadwaj, Mitasha, Müller, Daniel J, Zuchtriegel, Gabriele, Reichel, Christoph A, Costell, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279944/
https://www.ncbi.nlm.nih.gov/pubmed/28092265
http://dx.doi.org/10.7554/eLife.22264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279944/
https://www.ncbi.nlm.nih.gov/pubmed/28092265
http://dx.doi.org/10.7554/eLife.22264

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