Cargando…

IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells

The pathogenic process of intervertebral disc degeneration (IDD) is characterized by imbalance in the extracellular matrix (ECM) metabolism. Nucleus pulposus (NP) cells have important roles in maintaining the proper structure and tissue homeostasis of disc ECM. These cells need adequate supply of gl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xinghuo, Song, Yu, Liu, Wei, Wang, Kun, Gao, Yong, Li, Shuai, Duan, Zhenfeng, Shao, Zengwu, Yang, Shuhua, Yang, Cao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5280875/ https://www.ncbi.nlm.nih.gov/pubmed/28149534 http://dx.doi.org/10.1038/cddiscovery.2016.107

Ejemplares similares

The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration
por: Wu, Xinghuo, et al.
Publicado: (2016)

Methylation of microRNA-129-5P modulates nucleus pulposus cell autophagy by targeting Beclin-1 in intervertebral disc degeneration
por: Zhao, Kangcheng, et al.
Publicado: (2017)

Angiopoietin‐like protein 8 expression and association with extracellular matrix metabolism and inflammation during intervertebral disc degeneration
por: Liao, Zhiwei, et al.
Publicado: (2019)

Regulated cell death: Implications for intervertebral disc degeneration and therapy
por: Yang, Fan, et al.
Publicado: (2022)

Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy
por: Liu, Jintao, et al.
Publicado: (2022)

Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells
por: Wu, Xinghuo, et al.
Publicado: (2017)

An in vivo study of the effect of c-Jun on intervertebral disc degeneration in rats
por: Lei, Ming, et al.
Publicado: (2021)

Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis
por: Hu, Bo, et al.
Publicado: (2022)

Extracellular matrix remodeling in experimental intervertebral disc degeneration
por: de Oliveira, Cintia Pereira, et al.
Publicado: (2013)

The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
por: Li, Hao, et al.
Publicado: (2022)

Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis
por: Lin, Zhen, et al.
Publicado: (2021)

Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration
por: Li, Shuai, et al.
Publicado: (2021)

Intervertebral Disc-Derived Stem/Progenitor Cells as a Promising Cell Source for Intervertebral Disc Regeneration
por: Hu, Binwu, et al.
Publicado: (2018)

ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells
por: Cai, Xianyi, et al.
Publicado: (2018)

Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration
por: Wang, Bingjin, et al.
Publicado: (2021)

Intervertebral Disc Tissue Engineering with Natural Extracellular Matrix-Derived Biphasic Composite Scaffolds
por: Xu, Baoshan, et al.
Publicado: (2015)

IGF Signaling in Intervertebral Disc Health and Disease
por: Lin, Hui, et al.
Publicado: (2022)

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration
por: Kang, Liang, et al.
Publicado: (2019)

JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix
por: Long, Jun, et al.
Publicado: (2019)

The c-Jun signaling pathway has a protective effect on nucleus pulposus cells in patients with intervertebral disc degeneration
por: Lei, Ming, et al.
Publicado: (2020)

Selective cargo sorting in stem cell‐derived small extracellular vesicles: impact on therapeutic efficacy for intervertebral disc degeneration
por: Liao, Zhiwei, et al.
Publicado: (2023)

Heparanase isoform expression and extracellular matrix remodeling in intervertebral disc degenerative disease
por: Rodrigues, Luciano Miller Reis, et al.
Publicado: (2011)

The presence of extracellular matrix degrading metalloproteinases during fetal development of the intervertebral disc
por: Rutges, J. P. H. J., et al.
Publicado: (2010)

Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc
por: Wu, Xinghuo, et al.
Publicado: (2019)

FoxO1a mediated cadmium‐induced annulus fibrosus cells apoptosis contributes to intervertebral disc degeneration in smoking
por: Jing, Doudou, et al.
Publicado: (2020)

Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix
por: Empere, Marta, et al.
Publicado: (2023)

Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway
por: Wang, Dong, et al.
Publicado: (2020)

The role of oxidative stress in intervertebral disc cellular senescence
por: Cheng, Fengqi, et al.
Publicado: (2022)

Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway
por: Zhan, Shengfeng, et al.
Publicado: (2019)

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo
por: Liao, Zhiwei, et al.
Publicado: (2021)

Biomaterials-Induced Stem Cells Specific Differentiation Into Intervertebral Disc Lineage Cells
por: Peng, Yizhong, et al.
Publicado: (2020)

Ginsenoside Rg1 inhibits nucleus pulposus cell apoptosis, inflammation and extracellular matrix degradation via the YAP1/TAZ pathway in rats with intervertebral disc degeneration
por: Yang, Yong-hua, et al.
Publicado: (2022)

Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration
por: Song, Yu, et al.
Publicado: (2018)

Atomic force microscopy imaging for nanoscale and microscale assessments of extracellular matrix in intervertebral disc and degeneration
por: Cauble, Meagan A., et al.
Publicado: (2020)

Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy
por: Chen, Jiangwei, et al.
Publicado: (2019)

Extra Cellular Matrix Remodeling: An Adjunctive Target for Spinal Cord Injury and Intervertebral Disc Degeneration
por: Kumar, Ashish, et al.
Publicado: (2022)

The circadian rhythm in intervertebral disc degeneration: an autophagy connection
por: Zhang, Tai-Wei, et al.
Publicado: (2020)

Matrix metalloproteinases (MMP’s) in the rat scoliotic intervertebral disc
por: Grivas, Theodoros B, et al.
Publicado: (2010)

Effect of a Type II Collagen Fragment on the Expression of Genes of the Extracellular Matrix in Cells of the Intervertebral Disc
por: Mwale, F, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_omuvgdhlh1ve7pc7nqkijrlls5