Suicide Inhibition of Cytochrome P450 Enzymes by Cyclopropylamines via a Ring-Opening Mechanism: Proton-Coupled Electron Transfer Makes a Difference

N-benzyl-N-cyclopropylamine (BCA) has been attracting great interests for decades for its partial suicide inactivation role to cytochrome P450 (P450) via a ring-opening mechanism besides acting as a role of normal substrates. Understanding the mechanism of such partial inactivation is vital to the c...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoqian, Li, Xiao-Xi, Liu, Yufang, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281577/
https://www.ncbi.nlm.nih.gov/pubmed/28197402
http://dx.doi.org/10.3389/fchem.2017.00003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281577/
https://www.ncbi.nlm.nih.gov/pubmed/28197402
http://dx.doi.org/10.3389/fchem.2017.00003

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