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The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel

Transient receptor potential ankyrin 1 (TRPA1) is an excitatory ion channel involved in pain, inflammation and itching. This channel gates in response to many irritant and proalgesic agents, and can be modulated by calcium and depolarizing voltage. While the closed-state structure of TRPA1 has been...

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Detalles Bibliográficos
Autores principales: Marsakova, Lenka, Barvik, Ivan, Zima, Vlastimil, Zimova, Lucie, Vlachova, Viktorie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281607/
https://www.ncbi.nlm.nih.gov/pubmed/28197074
http://dx.doi.org/10.3389/fnmol.2017.00016