Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes

We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA...

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Detalles Bibliográficos
Autores principales: Kwack, Kyu Hwan, Lee, Hyeon-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282443/
https://www.ncbi.nlm.nih.gov/pubmed/28194047
http://dx.doi.org/10.1155/2017/7682083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282443/
https://www.ncbi.nlm.nih.gov/pubmed/28194047
http://dx.doi.org/10.1155/2017/7682083

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