Cargando…

Young Bone-Marrow Sca-1(+) Stem Cells Rejuvenate the Aged Heart and Improve Function after Injury through PDGFRβ-Akt pathway

Bone marrow (BM) reconstitution with young BM cells in aged recipients restores the functionality of cardiac resident BM-derived progenitors. This study investigated the cell type primarily responsible for this effect. We reconstituted old mice with BM cells from young or old mice and found that the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shu-Hong, Sun, Lu, Yang, Lei, Li, Jiao, Shao, Zhengbo, Du, Guo-Qing, Wu, Jun, Weisel, Richard D., Li, Ren-Ke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282531/ https://www.ncbi.nlm.nih.gov/pubmed/28139736 http://dx.doi.org/10.1038/srep41756

Ejemplares similares

Young Bone Marrow Sca-1 Cells Rejuvenate the Aged Heart by Promoting Epithelial-to-Mesenchymal Transition
por: Li, Jiao, et al.
Publicado: (2018)

Young Bone Marrow Sca-1 Cells Rejuvenate the Aged Heart by Promoting Epithelial-to-Mesenchymal Transition: Erratum
por: Li, Jiao, et al.
Publicado: (2023)

Long‐term repopulation of aged bone marrow stem cells using young Sca‐1 cells promotes aged heart rejuvenation
por: Li, Jiao, et al.
Publicado: (2019)

Young bone marrow Sca‐1 cells protect aged retina from ischaemia‐reperfusion injury through activation of FGF2
por: Shao, Zhengbo, et al.
Publicado: (2018)

Targeting aged bone marrow for systemic rejuvenation
por: Alibhai, Faisal J., et al.
Publicado: (2020)

Translating bone marrow rejuvenation from the bench to beside
por: Alibhai, Faisal J., et al.
Publicado: (2022)

Neuroprotective effects of bone marrow Sca-1(+) cells against age-related retinal degeneration in OPTN E50K mice
por: Liu, Xinna, et al.
Publicado: (2021)

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche
por: Kuribayashi, Wakako, et al.
Publicado: (2020)

Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1(+) stem cells from young donors
por: Wlodarek, Lukasz, et al.
Publicado: (2020)

PDGFRα demarcates the cardiogenic clonogenic Sca1(+) stem/progenitor cell in adult murine myocardium
por: Noseda, Michela, et al.
Publicado: (2015)

Aged Human Multipotent Mesenchymal Stromal Cells Can Be Rejuvenated by Neuron-Derived Neurotrophic Factor and Improve Heart Function After Injury
por: Song, Hui-Fang, et al.
Publicado: (2017)

Tissue-resident Sca1+ PDGFRα+ mesenchymal progenitors are the cellular source of fibrofatty infiltration in arrhythmogenic cardiomyopathy
por: Paylor, Ben, et al.
Publicado: (2013)

Cell fusion contributes to the rescue of apoptotic cardiomyocytes by bone marrow cells
por: Yang, Wei-Jian, et al.
Publicado: (2012)

Potential of bone marrow mesenchymal stem cells in rejuvenation of the aged skin of rats
por: Liu, Zhen, et al.
Publicado: (2017)

Rejuvenation of Senescent Bone Marrow Mesenchymal Stromal Cells by Pulsed Triboelectric Stimulation
por: Li, Gaocai, et al.
Publicado: (2021)

Understanding systemic factors in aging and rejuvenation
por: Alibhai, Faisal J., et al.
Publicado: (2020)

PDGFRα/Sca-1 Sorted Mesenchymal Stromal Cells Reduce Liver Injury in Murine Models of Hepatic Ischemia-Reperfusion Injury
por: Owen, Andrew, et al.
Publicado: (2022)

Frequency of SCA8, SCA10, SCA12, SCA36, FXTAS and C9orf72 repeat expansions in SCA patients negative for the most common SCA subtypes
por: Aydin, Gülsah, et al.
Publicado: (2018)

Analysis of SCA8, SCA10, SCA12, SCA17 and SCA19 in patients with unknown spinocerebellar ataxia: a Thai multicentre study
por: Choubtum, Lulin, et al.
Publicado: (2015)

Young at Heart: Combining Strategies to Rejuvenate Endogenous Mechanisms of Cardiac Repair
por: Maghin, Edoardo, et al.
Publicado: (2020)

Murine Sca1(+)Lin(−) bone marrow contains an endodermal precursor population that differentiates into hepatocytes
por: Oh, Keunhee, et al.
Publicado: (2015)

Knock‐out of MicroRNA 145 impairs cardiac fibroblast function and wound healing post‐myocardial infarction
por: Song, Hui‐Fang, et al.
Publicado: (2020)

Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells
por: Eroglu, Binnur, et al.
Publicado: (2021)

PDGFA/PDGFRα-regulated GOLM1 promotes human glioma progression through activation of AKT
por: Xu, Ran, et al.
Publicado: (2017)

Differentiation-Associated MicroRNA Alterations in Mouse Heart-Derived Sca-1(+)CD31(−) and Sca-1(+)CD31(+) Cells
por: Wu, Qiong, et al.
Publicado: (2016)

The tale of young blood rejuvenating the old
por: Chu, Xiaogang, et al.
Publicado: (2023)

Low/Negative Expression of PDGFR-α Identifies the Candidate Primary Mesenchymal Stromal Cells in Adult Human Bone Marrow
por: Li, Hongzhe, et al.
Publicado: (2014)

Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats
por: Taguchi, Akihiko, et al.
Publicado: (2011)

Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease
por: Kang, Seokjo, et al.
Publicado: (2020)

Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells
por: Gong, Liangzhi, et al.
Publicado: (2020)

The Aging Heart: Mitophagy at the Center of Rejuvenation
por: Liang, Wenjing J., et al.
Publicado: (2020)

AKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development
por: Wan, Xiaofeng, et al.
Publicado: (2021)

Forever young: rejuvenating muscle satellite cells
por: Madaro, Luca, et al.
Publicado: (2015)

From Old to Young: Rejuvenation in The Waste Land
por: Hwang, Kun
Publicado: (2022)

The rejuvenating influence of young plasma on aged intestine
por: Ceylani, Taha, et al.
Publicado: (2023)

Cytokines Inducing Bone Marrow SCA(+) Cells Migration into Pancreatic Islet and Conversion into Insulin-Positive Cells In Vivo
por: Luo, LuGuang, et al.
Publicado: (2009)

Gene Expression Profile and Functionality of ESC-Derived Lin-ckit+Sca-1+ Cells Are Distinct from Lin-ckit+Sca-1+ Cells Isolated from Fetal Liver or Bone Marrow
por: Fernandez, Irina, et al.
Publicado: (2012)

Activation of PI3K/AKT and MAPK Pathway through a PDGFRβ-Dependent Feedback Loop Is Involved in Rapamycin Resistance in Hepatocellular Carcinoma
por: Li, Quan-Lin, et al.
Publicado: (2012)

Heart Failure Impairs Bone Marrow Hematopoietic Stem Cell Function and Responses to Injury
por: Marvasti, Tina B., et al.
Publicado: (2023)

Consequences of PDGFRα(+) fibroblast reduction in adult murine hearts
por: Kuwabara, Jill T, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ra479cb2ap1j5a4bg0b3fkoh65