The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site

Methyl-CpG binding protein 2 (MeCP2) preferentially interacts with methylated DNA and it is involved in epigenetic regulation and chromatin remodelling. Mutations in MeCP2 are linked to Rett syndrome, the leading cause of intellectual retardation in girls and causing mental, motor and growth impairm...

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Detalles Bibliográficos
Autores principales: Claveria-Gimeno, Rafael, Lanuza, Pilar M., Morales-Chueca, Ignacio, Jorge-Torres, Olga C., Vega, Sonia, Abian, Olga, Esteller, Manel, Velazquez-Campoy, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282554/
https://www.ncbi.nlm.nih.gov/pubmed/28139759
http://dx.doi.org/10.1038/srep41635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282554/
https://www.ncbi.nlm.nih.gov/pubmed/28139759
http://dx.doi.org/10.1038/srep41635

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