The β and γ subunits play distinct functional roles in the α(2)βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase

Human NAD-dependent isocitrate dehydrogenase existing as the α(2)βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. To explore the functional roles of the regulatory β and γ subunits, we sys...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Tengfei, Peng, Yingjie, Huang, Wei, Liu, Yabing, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282582/
https://www.ncbi.nlm.nih.gov/pubmed/28139779
http://dx.doi.org/10.1038/srep41882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282582/
https://www.ncbi.nlm.nih.gov/pubmed/28139779
http://dx.doi.org/10.1038/srep41882

Ejemplares similares