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The β and γ subunits play distinct functional roles in the α(2)βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase
Human NAD-dependent isocitrate dehydrogenase existing as the α(2)βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. To explore the functional roles of the regulatory β and γ subunits, we sys...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282582/ https://www.ncbi.nlm.nih.gov/pubmed/28139779 http://dx.doi.org/10.1038/srep41882 |