The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity

Many side effects of current FDA-approved L-asparaginases have been related to their secondary L-glutaminase activity. The Wolinella succinogenes L-asparaginase (WoA) has been reported to be L-glutaminase free, suggesting it would have fewer side effects. Unexpectedly, the WoA variant with a proline...

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Detalles Bibliográficos
Autores principales: Nguyen, Hien Anh, Durden, Donald L., Lavie, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282591/
https://www.ncbi.nlm.nih.gov/pubmed/28139703
http://dx.doi.org/10.1038/srep41643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282591/
https://www.ncbi.nlm.nih.gov/pubmed/28139703
http://dx.doi.org/10.1038/srep41643

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