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Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania

BACKGROUND: 5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomes of a diverse range of organisms. To explore the functional importance of 5hmU, we develop a method for the genome-wide mapping of 5hmU-modified loci based on a chemical tagging strategy for the hydroxymethyl...

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Detalles Bibliográficos
Autores principales:	Kawasaki, Fumiko, Beraldi, Dario, Hardisty, Robyn E., McInroy, Gordon R., van Delft, Pieter, Balasubramanian, Shankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282726/ https://www.ncbi.nlm.nih.gov/pubmed/28137275 http://dx.doi.org/10.1186/s13059-017-1150-1

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