Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets

Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-coding RNAs. Alterations in epigenetic profiles cause deregulation of fundamental gene expre...

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Autores principales: Lindsay, Cameron, Seikaly, Hadi, Biron, Vincent L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282807/
https://www.ncbi.nlm.nih.gov/pubmed/28143553
http://dx.doi.org/10.1186/s40463-017-0185-3
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author Lindsay, Cameron
Seikaly, Hadi
Biron, Vincent L.
author_facet Lindsay, Cameron
Seikaly, Hadi
Biron, Vincent L.
author_sort Lindsay, Cameron
collection PubMed
description Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-coding RNAs. Alterations in epigenetic profiles cause deregulation of fundamental gene expression pathways associated with carcinogenesis. The role of epigenetics in oropharyngeal squamous cell carcinoma (OPSCC) has recently been recognized, with implications for novel biomarkers, molecular diagnostics and chemotherapeutics. In this review, important epigenetic pathways in human papillomavirus (HPV) positive and negative OPSCC are summarized, as well as the potential clinical utility of this knowledge. This material has never been published and is not currently under evaluation in any other peer-reviewed publication.
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spelling pubmed-52828072017-02-06 Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets Lindsay, Cameron Seikaly, Hadi Biron, Vincent L. J Otolaryngol Head Neck Surg Review Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-coding RNAs. Alterations in epigenetic profiles cause deregulation of fundamental gene expression pathways associated with carcinogenesis. The role of epigenetics in oropharyngeal squamous cell carcinoma (OPSCC) has recently been recognized, with implications for novel biomarkers, molecular diagnostics and chemotherapeutics. In this review, important epigenetic pathways in human papillomavirus (HPV) positive and negative OPSCC are summarized, as well as the potential clinical utility of this knowledge. This material has never been published and is not currently under evaluation in any other peer-reviewed publication. BioMed Central 2017-01-31 /pmc/articles/PMC5282807/ /pubmed/28143553 http://dx.doi.org/10.1186/s40463-017-0185-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Lindsay, Cameron
Seikaly, Hadi
Biron, Vincent L.
Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
title Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
title_full Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
title_fullStr Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
title_full_unstemmed Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
title_short Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
title_sort epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282807/
https://www.ncbi.nlm.nih.gov/pubmed/28143553
http://dx.doi.org/10.1186/s40463-017-0185-3
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