Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing

BACKGROUND: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson’s disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated participants. To discover rare PD susceptibility variants, we performed WES in 11...

Descripción completa

Detalles Bibliográficos
Autores principales: Jansen, Iris E., Ye, Hui, Heetveld, Sasja, Lechler, Marie C., Michels, Helen, Seinstra, Renée I., Lubbe, Steven J., Drouet, Valérie, Lesage, Suzanne, Majounie, Elisa, Gibbs, J. Raphael, Nalls, Mike A., Ryten, Mina, Botia, Juan A., Vandrovcova, Jana, Simon-Sanchez, Javier, Castillo-Lizardo, Melissa, Rizzu, Patrizia, Blauwendraat, Cornelis, Chouhan, Amit K., Li, Yarong, Yogi, Puja, Amin, Najaf, van Duijn, Cornelia M., Morris, Huw R., Brice, Alexis, Singleton, Andrew B., David, Della C., Nollen, Ellen A., Jain, Shushant, Shulman, Joshua M., Heutink, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282828/
https://www.ncbi.nlm.nih.gov/pubmed/28137300
http://dx.doi.org/10.1186/s13059-017-1147-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282828/
https://www.ncbi.nlm.nih.gov/pubmed/28137300
http://dx.doi.org/10.1186/s13059-017-1147-9

Ejemplares similares