Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer

Tumor-associated or -infiltrating lymphocytes (TALs or TILs) co-express multiple immune inhibitory receptors that contribute to immune suppression in the ovarian tumor microenvironment (TME). Dual blockade of PD-1 along with LAG-3 or CTLA-4 has been shown to synergistically enhance T-cell effector f...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Ruea-Yea, Francois, Ariel, McGray, AJ Robert, Miliotto, Anthony, Odunsi, Kunle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283642/
https://www.ncbi.nlm.nih.gov/pubmed/28197366
http://dx.doi.org/10.1080/2162402X.2016.1249561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283642/
https://www.ncbi.nlm.nih.gov/pubmed/28197366
http://dx.doi.org/10.1080/2162402X.2016.1249561

Ejemplares similares